Production of plasma esterified cholesterol in lean, normotriglyceridemic humans
نویسندگان
چکیده
منابع مشابه
Production of plasma esterified cholesterol in lean, normotriglyceridemic humans.
The rate of production of plasma esterified cholesterol was measured both in vivo and in vitro in seven subjects and in vivo alone in eight subjects. All subjects were lean, clinically healthy, and had triglyceride concentrations less than 1.5 micro moles/ml. In vivo production was calculated from the labeling of free and esterified cholesterol in plasma samples collected at 1-hr intervals for ...
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Knowledge concerning the formation and transport of esterified cholesterol in plasma is fundamental to an understanding of the mechanisms by which cholesterol is delivered to peripheral tissues from the liver and removed from these tissues for recycling or excretion through the liver. Hepatic cholesterol enters the plasma in man predominantly in the unesterified, or free, form as a component of...
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In two subjects the specific activity of esterified cholesterol in plasma lipoprotein subfractions was measured for up to 9 hr after an intravenous injection of [(3)H]mevalonic acid. It was found to be consistently higher in larger (S(f) > 100) than in smaller (S(f) 20-100) very low density lipoproteins (VLDL). Four subjects were given an intravenous injection of heparin so that the VLDL could ...
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In order to determine the in vivo influx of plasma cholesterol into human aortic intimamedia tissue, specimens of the ascending aortic wall without visible atherosclerosis were obtained from patients undergoing aortic valve replacement. Before the operation the patients were intravenously injected with autologous plasma in which the lipoproteins were labeled with radioactive cholesterol. The in...
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Coronary heart diseases (CHD) is a multifactorial disease which is responsible for more than half a million deaths every year in the United States (Consensus Conference, 1985). Among the risk factors implicated in the genesis of CHD, hypercholesterolemia is a primary one. (Stamler et al., 1986). Epidemiological, clinical, and anatomo-pathological studies (Keys, 1970; Stamler et al., 1986; Solbe...
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ژورنال
عنوان ژورنال: Journal of Lipid Research
سال: 1974
ISSN: 0022-2275
DOI: 10.1016/s0022-2275(20)36801-2